In 1908, a brilliant American battleship gun designer dies in a sensational apparent suicide. The man's grief-stricken daughter turns to the legendary Van Dorn Detective Agency to clear her father's name. Van Dorn puts his chief investigator on the case, and Isaac Bell soon realizes that the clues point not to suicide but to murder.

It is 1902, and Isaac Bell is investigating sabotage in a West Virginia coal mine. But when he stops a runaway train, saving countless lives, Bell discovers that it is part of a conspiracy to frame striking miners. From West Virginia to Pittsburgh, New York City and Cincinnati, Bell is now on the hunt for clues to discover who is behind this murderous scheme. It puts him up against a ruthless agent provocateur allied to a cabal of staggering ambition...