The voice of Music narrates the tale of its most beloved disciple, young Frankie Presto, a war orphan raised by a blind music teacher in a small Spanish town. At nine years old, Frankie is sent to America in the bottom of a boat. His only possession is an old guitar and six precious strings. But Frankie's talent is touched by the gods, and his amazing journey weaves him through the musical landscape of the 20th century, from classical to jazz to rock...

After his eleven-year-old son dies, guitarist Quinn Porter does yard work for an aged Lithuanian immigrant, Ona Vitkus, whom his son had often visited and comes to a resolution about his son's death as Ona discusses his son's capacity to listen and learn.

When she discovers that her boyfriend is cheating on her, Sydney, a college student, must decide what to do next. She becomes captivated by her mysterious neighbor Ridge, and can't stop listening to the passionate way he plays his guitar every evening out on his balcony. They soon find themselves needing each other in more ways than one.