Still pursuing a cure for her mother's enchantment, Clary uses all her powers and ingenuity to get into Idris, the forbidden country of the secretive Shadowhunters, and to its capital, the City of Glass, where with the help of a newfound friend, Sebastian, she uncovers important truths about her family's past that will not only help save her mother but all those that she holds most dear.

A vampiric virus infects New York and spreads outward, threatening the city and then the world, as a CDC doctor and a Holocaust survivor fight to save humanity.

Robert Neville is the last human survivor in what is left of New York City. A pandemic has left only 1% of the population alive and most of those who survived are no longer human. The infected, now lurking in the shadows, watch Neville's every move. Perhaps mankind's last, best hope, Neville is driven by the only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood.

In the sixth installment, the survivors of the Ghostface killings leave Woodsboro behind and start afresh in New York City.